Mechanisms of Murine Mammary Tumorigenesis: Cooperation Between Tyrosine kinase Receptors and Mutant p53
Abstract
A mouse model for human breast cancer closely mimics the genetic changes that occur in the human disease. Twenty-five to 30% of human breast cancers show amplification and overexpression of the neu (also known as HER2 or ErbB2) gene, and of these, many will have point mutations in p53. The 175H mutation of p53 is the most common p53 mutation in human breast cancers, and is often accompanied by loss of the other allele, arguing that it is not simply acting as a dominant negative. Thus, we have created a useful model for the study of human breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADA366921
Entities
People
- Archibald S Perkins
Organizations
- Yale University