Molecular Mechanisms of Dietary Fatty Acids on Breast Cancer Growth and Development
Abstract
The link between diet and cancer has been long postulated and recently, extensively investigated. Elucidation of the mechanism between this link, however, has remained elusive. Recently, a cellular receptor called the peroxisomal proliferator-activated receptor (PPAR) has been identified which, when activated, is capable of inducing liver tumors. Activators of this receptor include a group of structurally diverse compounds that include fibrate hypolipidemic drugs, phthalate plasticizers and herbicides. Recently, it has been shown that this receptor is capable of binding and being activated directly by poly unsaturated fatty-acids (PUPA). We now have evidence that PPAR is present in breast cancer cells and may provide a direct link between diet and the increased rate of breast cancers seen in this country. These studies may lead to better understanding of the risk of specific dietary components. The data presented in this report make it clear that fatty acids can indeed function as hormones and this information could lead to important information regarding dietary guidelines and could be of significant therapeutic value. The implications of these studies could have a profound impact on both prevention and management of this devastating disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1999
- Accession Number
- ADA366971
Entities
People
- Michael W. Kilgore
Organizations
- Clemson University