Determination of Partition Coefficients for Trichloroethanol (TCOH) and Chloral Hydrate (CH)-Two Metabolites of Trichloroethylene (TCE).
Abstract
Trichioroethylene (TCE), a common groundwater contaminant, has been shown to be carcinogenic in some animal species. To determine the risk in humans, the use of physiologically-based pharmacokinetic models (PBPK) has become increasingly the method of choice. Formerly it was a common practice to calculate risk estimates on the basis of administered dose-toxicity/tumor incidence, it is now recognized that the dose delivered to the target organ is more accurate. Determination of partition coefficients (the solubility of the chemical in tissue) is one element important in the development of the PBPK model. This study focuses on two metabolites of TCE, chloral hydrate (CH) and trichloroethanol (TCOH). All studies were conducted in B(sub 6)C(sub 3)F(sub 1) mice since this species was used in the NCI/NTP carcinogenicity studies on TCE. Partition coefficients for CH and TCOH were determined using the nonvolatile method of Jepson et al., (Fund. and Appl. Tox 22:1994). Tissues used in CH studies were pre-treated with 20% lead acetate to insure no metabolism occurred during the incubation period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1995
- Accession Number
- ADA367278
Entities
People
- B. L. Garrity
- C. Seckel
- J. R. Creech
- R. K. Black