Stability and Concentration Verification of Ammonium Perchlorate Dosing Solutions
Abstract
Stability and concentration verification was performed for the ammonium perchlorate dosing solutions used in the on-going 90-Day Oral Toxicity Study conducted by Springborn Laboratories, Inc. (SLI Study No. 3433.1) and the Neurobehavioral Development study conducted by Argus Research Laboratories, Inc. (SS No. 7757A2l0-1096-25F). A sensitive and selective ion chromatography (IC) method for the analysis of perchlorate (ClO4)(-) and nitrate (NO3)(-), a possible interference anion, was developed to support these studies. The method development, and validation data more than sufficiently demonstrated that the IC method was capable of detecting both perchlorate and nitrate at 0.003 microgram/mL (5 ppb) in reagent water with excellent accuracy and precision. Ion chromatographic analysis of the stability solutions showed that under controlled room temperature, relative humidity and light intensity, ammonium perchlorate was stable in reagent water for at least 109 days. The concentrations of the ammonium perchlorate dosing solutions (0.05 to 200 micrograms/mL) were verified by IC analysis to be within an acceptable range of +/- 10%.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1998
- Accession Number
- ADA367416
Entities
People
- David R. Mattie
- David T. Tsui
- Latha Narayanan