Role of the erbB3 Gene Product in Breast Cancer Cell Proliferation
Abstract
The role of the ErbB3 protein in breast cancer cell proliferation was examined. In the first year of funding, it was demonstrated that the ErbB3 protein, although possessing a protein tyrosine kinase (PTK) homology domain, is in fact devoid of intrinsic PTK activity. In the second year of funding, we demonstrated the critical dependence of heregulin signaling upon the PTK activity of the ErbB2 protein, and characterized the interaction of ErbB3 with phosphoinositide (PI) 3-kinase in breast cancer cells. In the third year of funding, we identified the tyrosine residue in ErbB3 responsible for binding the Shc adapter protein, clarified the role of Shc in activation of the Ras/mitogen-activated protein kinase (MAPK) pathway, and began an exhaustive examination of other tyrosine residues in the ErbB3 C-terminus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADA367566
Entities
People
- John G. Koland
Organizations
- University of Iowa