Comparative Neurobehavioral Toxicity Assessment of Three Hydrocarbon Fuels.
Abstract
There is increasing evidence that repeated human occupational exposure to low concentrations of fuels can result in significant changes in neurobehavioral capacity. Recent evidence indicates that repeated exposure of rodents to jet fuel vapor/aerosol can induce significant changes in physiological function. To evaluate the neurobehavioral consequences of repeated fuel vapor exposures, groups of 32 male Sprague-Dawley rats were exposed for 6 hr/day, 5 days/week, for 6 consecutive weeks, to JP-8 (1 mg/L) jet fuel, JP-5 jet fuel, or diesel fuel vapor in whole body inhalation chambers. Three groups of 16 control rats each were similarly exposed to room air. Following whole body exposures, rats were rested for 65 days then were evaluated for neurobehavioral changes on%a battery often performance tests selected from the Neurobehavioral Toxicity Assessment Battery (NTAB). Following sacrifice, rats were assayed for changes in brain or serum neurotransmitter levels, and for functional or anatomical changes in the lungs, liver and testes. Results of this investigation are compared to data reported previously for fuel industry workers exposed to jet fuel vapors for up to 32 years.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADA368457
Entities
People
- Alan F. Nordholm
Organizations
- Naval Medical Research Center