The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family which binds to and activates the EGF-receptor. Its role in breast cancer, however, is unclear. We have studied the mechanism of induction of HB-EGF by EGF in the spontaneously immortalized mammary epithelial cell line MCF-l0A and in MCF-10A cells that have been transformed with oncogenic Ha-ras. The levels of EGFR, erbB-2 and erbB-3 were very similar in the nontransformed and in the transformed MCF-10A cells. However, the levels of mitogen- activated protein kinase (MAPK) were elevated in the MCF-10A cells transformed with the Ha-ras oncogene.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1998
Accession Number
ADA368480

Entities

People

  • David S. Salomon

Organizations

  • National Institutes of Health

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Growth Factors
  • Inhibition
  • Inhibitors
  • Materials
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Tyrosine

Readers

  • Breast cancer cell signaling and growth regulation.