Adipocyte Differentiation: Relationship to Breast Cancer.
Abstract
Desmoplastic reaction, i.e., intra- and peritumoral accumulation of fibroblasts provides structural and molecular support for breast tumors. This process of accumulation of fibroblasts around malignant epithelial cells in breast tumors is an active event mediated by malignant cells via endocrine manipulation of the surrounding stromal cells. In this instance, the destiny of the yet undifferentiated adipose fibroblast is the target cell. The secretory products of malignant cells, which have been identified as certain cytokines prevent the differentiation of adipose fibroblasts into mature adipocytes. This is the major mechanism for desmoplastic reaction, since malignant epithelial cells do not induce proliferation of adipose fibroblasts. We also identified the key adipogenic transcription factors that were inhibited by malignant epithelial cells. We are currently evaluating the effects of these factors on the promoter activity of molecules that are important markers for the undifferentiated state of adipose fibroblasts. We are also determining the distribution of expression of adipogenic transcription factors and antiadipogenic cytokines in breast tumors and surrounding tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA368529
Entities
People
- Serdar Bulun
Organizations
- University of Texas Southwestern Medical Center