Safety and Immunogenicity Testing of an Intranasal Group B Meningococcal Native Outer Membrane Vesicle Vaccine in Healthy Volunteers
Abstract
An intranasal vaccine composed of native outer membrane vesicles (NOMV) not exposed to detergent or denaturing agents was prepared from the group B meningococcal strain and tested in 32 healthy adult volunteers. Four groups of 8 volunteers were vaccinated intranasally with three doses of vaccine. The vaccine was very well tolerated in all dosing groups despite the presence of lipo-oligosaccharide in the vaccine at a level of 25% relative to protein. The antibody response as measured by ELISA in serum, saliva and nasal wash fluids was relatively low in all 4 groups but the induced serum antibodies had strong bactericidal activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 26, 1998
- Accession Number
- ADA369066
Entities
People
- Brenda L. Brandt
- David R. Shoemaker
- Elizabeth E. Moran
- Joseph J. Drabick
- Nancy B. Saunders
Organizations
- United States Army Medical Research and Development Command