Dermal Absorption of JP-8 Jet Fuel and Its Components
Abstract
The dermal absorption of jet fuels in general and JP-8 in particular is not well understood, even though the use by government and industry, worldwide, is over 59 billion gallons per year. JP-8, which is similar to kerosene, is composed of hundreds and perhaps thousands of hydrocarbon chemicals and their isomers. Exposures to JP-8 can occur from vapor, liquid or aerosol. Inhalation and dermal are the most prevalent routes of exposure. It is recognized that JP-8 may cause irritation when the skin is exposed repeatedly or for prolonged periods, but whether systemic toxicity from dermal absorption of fuels may occur is unknown. The purpose of this investigation was to measure the flux of JP-8 and its major constituents through rodent skin to assess the potential for systemic effects with human exposures. The composition of a specific test sample (POSF-35O9) of JP-8 was analyzed. Static diffusion cells containing dermatomed rodent skin were used to determine the flux of JP-8 and it's components. Thirteen individual components of JP-8 were identified in the receptor solution. The flux from this JP-8 fuel ranged from a high of 82.4 nanograms/cm2/hr (the additive DIEGME) to a low of 0.5 nanograms/cm2/hr (tridecane). Permeability coefficients, which can be used to estimate the absorption of components from other fuels, were also calculated. These fluxes suggest that JP-8 will not cause systemic toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1999
- Accession Number
- ADA369228
Entities
People
- Carol M. Garrett
- Daniel L. Pollard
- James Mcdougal
- Robert M. Davis
- Tomas E. Miller