Metalloprotease/Disintegrin Proteins and Mammary Carcinoma Progression.
Abstract
Protein families known to be important in regulating tissue architecture and cell behavior include integrins, cadherins, Ig-CAMS, collagens, proteoglycans, tenascins, thrombospondins, matrix metalloproteases (MMPs), and many others. However, there are additional protein families that are likely to be important, but thus far have not been investigated with respect to their distribution and function in mammary tumors. One of these is a recently recognized family of transmembrane proteins containing integrin-binding domains, metalloprotease domains, and cytoplasmic domains with potential signaling capacity. This unique domain structure suggests the intriguing possibility that these molecules may play critical roles in regulating extracellular matrix and integrin function in cell adhesion and invasion. The goal of this project is to identify members of this family that are expressed in breast cancer tissue, to develop novel antibodies to them, and to determine their distribution in tumor tissue as well as in cultured breast cancer cell lines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA369252
Entities
People
- Robert Pytela
Organizations
- University of California, San Francisco