Methyl-Deficient Diets and Risks of Breast Cancer Among African-American Women: A Case-Control Study by Methylation Status of the ER Gene.
Abstract
This report covers the period from September 25, 1997 to September 24, 1998, the first year of our project on methyl-deficient diets in relation to breast cancer according to the methylation status of the estrogen receptor (ER) gene GpG islands. During the period, we have obtained from another study 175 cases (170 interviewed) and 142 controls for this project. We have established collaborations with hospitals in the three counties in tumor tissue collection and collected 115 tumor tissue specimens. ER status of the collected tissue specimens is being measured. We have chosen a laboratory method for methylation measurement using paraffin- fixed tissue specimens, formulated laboratory procedures for the measurement, and conducted some preliminary tests. We have established and maintained a computer tracking system for the contacts with subjects and tumor tissue collection. We also have written an article on the study hypothesis on which this project is based. This article will be published in November 1998. In summary, this project has generally gone well according to the statement of work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA369318
Entities
People
- Kangmin Zhu
Organizations
- Meharry Medical College