Utilizing Serial Measures of Breast Cancer Risk Factors
Abstract
The overall goals of the project were to develop theoretical statistical methods for utilizing repeated measurements of serum levels of risk factors in epidemiologic studies of breast cancer. During the four year study period, the following research was accomplished: (1) a technique was developed for correcting for measurement error when subjects have a variable number of repeated exposure measurements; (2) the technique was applied to studies of endogenous estrogens and androgens and risk of post-menopausal breast cancer; (3) a method was developed for adjusting for the systematic variability of hormone levels over the menstrual cycle in studies of pre-menopausal breast cancer; (4) guidelines were devised for choosing the number of repeated measurements and optimal time interval between repeats in half-life studies of environmental contaminants which have been linked with an increased risk of breast cancer; (5) methodology was developed for analyzing correlated panel data which can arise when serially monitoring toxicity in clinical trials of breast cancer treatments; and (6) a conceptual approach based on equivalence testing was proposed for assessing the validity of a dietary assessment method for use in epidemiologic studies of breast cancer and other diseases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1999
- Accession Number
- ADA369628
Entities
People
- Mimi Y. Kim
Organizations
- NYU Langone Health