Genetic Epidemiology of in situ Breast Cancer
Abstract
This five year project will define risk factors associated with breast carcinoma in-situ through the mechanism of a case/control study. The study population consists of approximately 1100-1200 cases of female breast carcinoma in- situ (BCIS) and 1100-1200 age-matched female controls selected from the state of Connecticut. At the end of year four, case and control ascertainment is complete with 1537 eligible cases and 1285 eligible controls identified. Physicians have consented for 91% of eligible cases. Eighty-seven percent of contacted eligible cases and 85% of contacted eligible controls have agreed to participate in telephone interviews which collect information concerning family history of cancer, pregnancy and menstrual history, hormone replacement therapy, oral contraceptive use, fertility drug use, as well as sociodemographic variables. Preliminary analyses suggest that many of the risk factors traditionally associated with invasive breast cancer, including a family history of breast cancer, are also associated with the development of BCIS. In addition to the interview portion of the study, which is now essentially complete, the expression of p53, c-erbB-2 as well as estrogen and progesterone receptors will be examined in paraffin-blocks from a subset of cases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1998
- Accession Number
- ADA370308
Entities
People
- Elizabeth B. Claus
Organizations
- Yale University