Raid 4D MRI of GAD-DTPA Enhancement for Breast Lesion Characterization
Abstract
The aims of this project were refinement and implementation of new methods designed to defeat the tradeoff between spatial resolution, temporal resolution and tissue coverage in dynamic gadolinium-enhanced MR mammography. The approach involved specialized software for data acquisition and reconstruction to yield dynamic scans of 32 sections through both breasts acquired at 5-6 second temporal resolution. Additional post-processing reduced motion artifacts for improved quantitation via in numerical fitting of temporal enhancement properties of tissues. Technical objectives related to completion of data acquisition and processing methods were generally successful. This methodology was applied in a prospective 4-year study of 102 women referred for surgical biopsy of a breast abnormality detected by non-MRI means. The hypothesis that malignancies to will display a high contrast-enhancement rate was supported by the data RATE = (79 +/- 75)X10(EXP -3)/SEC, MEAN +/- STD DEV, N=39 relative to benign tissues RATE = (19 +/- 16)X10(EXP -3)/SEC, N=54, although some overlap exists. ROC analysis yields a sensitivity 85% and specificity 75% using an enhancement-rate threshold = 22x10(exp -3)/sec. These quantitative kinetic properties can be further combined with tissue/lesion morphology to further enhance specificity of breast MRI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1999
- Accession Number
- ADA370330
Entities
People
- Thomas L. Chenevert
Organizations
- University of Michigan