A New Class of Serine and Cysteine Protease Inhibitor with Chemotherapeutic Potential

Abstract

Metastasis and angiogenesis in cancer are dependent on a variety of biologically active compounds including serine protease. Inhibition of proteases such as plasmin is a potential route for suppression of both metastasis and angiogenesis. Synthesis of tetrahydrothiopyran-4-one based inhibitors containing either a dialkylamino chain, a lysine analog side chain and a dipeptide (D-ile-phe or D-ile-Trp), or just the D-ile-phe dipeptide was accomplished. A compound with both the lysine analog side chain and the dipeptide but lacking a carbonyl was also produced.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1999
Accession Number
ADA370850

Entities

People

  • Tanya C. Sanders

Organizations

  • Brown University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Blood
  • Blood Vessels
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Cysteine
  • Enzyme Inhibitors
  • Epithelial Cells
  • Fibrin Modulating Agents
  • Materials
  • Molecules
  • Neoplasms
  • Neutral Amino Acids
  • Recognition

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).