DNA Topoisomerase I-Targeted Therapy for Breast Cancer

Abstract

The specific aim of this work is to develop camptothecin (CPT) analogs for treatment of women with breast cancer. We evaluated these analogs using three biochemical tests: (1) inhibition of growth of breast cancer cells, (2) induction of topoisomerase I-mediated cleavage of DNA, and (3) reversal of DNA cleavage. Our results indicate that the 10,11-methylenedioxy CPT analog was effective in all three tests. Further, this analog was effective against MX-1 and MDA-231 human breast xenografts growing in nude mice. The 10, 11- methylenedioxy analog appears to be the best choice among the analogs examined, and we are currently pursuing moving this compound into clinical trials.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1999
Accession Number
ADA371201

Entities

People

  • Daniel D. Von Hogg
  • Shih-fon Chen

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Antineoplastic Agents
  • Biochemistry
  • Biological Sciences
  • Blood Proteins
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Clinical Trials
  • Enzyme Inhibitors
  • Health Services
  • Inhibition
  • Medical Personnel
  • Neoplasms
  • Organic Chemistry

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).