Identification of Novel Candidate Tumor Suppressor Genes Using C. elegans as a Model.

Abstract

Molecular genetic analysis of the model organism Caenorhabditis elegans was used to identify and study mechanisms of action of negative regulators of tyrosine kinase/RAS mediated signal transduction that are candidate tumor suppressors. A homolog of the proto oncogene cbl, SLI-1, inhibits Ras activation by the epidermal growth factor receptor homolog LET-23. A missense mutation in the RING finger region of SLI-1 has been identified and provides are reagent to analyze the function of this domain. New screens for additional negative regulators have identified at least four genes that are now being analyzed.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1998
Accession Number
ADA371300

Entities

People

  • Paul W. Sternberg

Organizations

  • California Institute of Technology

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosomes
  • Genes
  • Genetic Phenomena
  • Genetically Modified Organisms
  • Genetics
  • Growth Factors
  • Identification
  • Laboratory Animals
  • Lymphocytes
  • Molecular Genetics
  • Mutations
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Marine Ecological Systems Migration
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology