Skin Blood Flow Responses and Forearm Reactive Hyperemia After Niacin Ingestion.
Abstract
Skin blood flow and core temperature were measured before and after niacin ingestion in eight subjects. Each subject was tested on two occasions in climatic conditions of 30 deg C with moderate humidity. Following niacin ingestion, peak forearm blood flow (FBF) by venous occlusion plethysmography averaged 8.0(1.7) ml/100ml/min from an average baseline of 2.2(0.5) ml/100ml/min, an increase of 265%. Forearm skin blood flow (laser doppler flowmetry, LDF) increased 310% (83) at peak niacin vasodilation to 13.1 (4.1) ml/100ml/min from the baseline of 3.4 (1.4) ml/100ml/min. Chest skin blood flow (LDF) increased 550% (154) compared to baseline. Higher skin blood flow significantly increased heat loss from the skin decreasing core temperature an average of 0.44 deg C (0.10) after niacin ingestion. Reactive hyperemia measured by laser doppler flowmetry in forearm skin upon the release of brachial arterial occlusion averaged 11.9 (1.7) ml/100ml/min, an increase of 250(110)% above control blood flow. This hyperemic response was 12% less than peak skin blood flow observed during the maximal niacin effect. Nicotinic acid, increased skin blood flow, increased skin temperature and decreased core temperature as we reported previously. Although widespread skin vasodilation occurred in most subjects, the extent of the vasodilation and the intensity of subjective symptoms varied within and between individuals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA372468
Entities
People
- Brent S. Mair
- Catherine L. Gabaree
- Lou A. Stephnson
- Margaret A. Kolka
Organizations
- United States Army Research Institute of Environmental Medicine