The Role of Protein Kinase-C in Breast Cancer Invasion and Metastasis.
Abstract
The Protein Kinase C (PKC) family of kinases lay a key role in the regulation of cell behavior. This final report for the proposal DAMD 1 7-94-J-4 166 describes our studies that set out to determine if particular isoforms of PKC are associated with a more malignant phenotype in human breast cancer. Expression of high levels of PKC-alpha and low levels of PKC-eta was associated with a more aggressive phenotype. Subsequent studies investigated the activity of two anti-PKC directed therapies in clinical trial.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA373385
Entities
People
- Michael D. Johnson
Organizations
- Georgetown University