Office of Naval Research Cooperative Agreement Number N00014-96-2-0016
Abstract
The objectives of activities conducted through this cooperative agreement were to: increase the availability of hematopoietic stem cell transplantation; improve scientific understanding of factors leading to successful post-transplant outcomes; and develop and test centralized contingency responses for the treatment of military and/or civilian casualties exposed to nuclear or biological marrow toxic agents. These objectives were successfully met through the following activities. The transition from serologic to DNA-based (molecular) technology for large scale HLA-A,B typing of newly recruited donors increased donor file size while improving the accuracy of the data used to match patients and donors. Continued molecular HLA-DR typing of large numbers of donors increased the percentage of patients identifying at least one potential donor from 78% to 86% during the period of the agreement. The increase in donor file size, complete and highly accurate typing of donors and enhancements to the NMDP computer system resulted in decreased search times. The data obtained from high resolution DNA-based typing of samples from stem cell recipients and their donors were correlated with post-transplant outcome data to evaluate the relationship between degree of match and successful patient outcomes. The results of these studies were disseminated through publications in peer-reviewed scientific journals and presentations at national conferences. Contingency plans for rapidly identifying stem cell donors for military or civilian casualties were developed. The plans were tested in conjunction with exercises led by the Department of Defense donor center.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 2000
- Accession Number
- ADA373386
Entities
People
- Dennis L Confer
- Janet Hegland
- Patricia A. Coppo
- R. D. Brown
- Robert Pinderhughes
Organizations
- National Marrow Donor Program