A Cell Culture Model for Understanding Estrogen Receptor Regulation in Normal and Malignant Cells.

Abstract

To characterize a spontaneous epithelial-to-mesenchymal conversion (EMT) in the non- transformed "functional normal" mammary epithelial cell line SCp2. Determine if the mesenchymal conversion in SCp2 cells is associated with tumorigenesis. Determine if alterations in growth factor expression and regulation are accompanied by changes in ECM and metalloproteinases expression. Determine if the presence of 3D structure is critical to stopping spontaneous and induced conversion.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1998
Accession Number
ADA373393

Entities

People

  • Mina Bissell
  • Virginia Novaro

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Cell Line
  • Cells
  • Chemical Compounds
  • Conversion
  • Culture Techniques
  • Epithelial Cells
  • Estrogens
  • Growth Factors
  • Hormones
  • Laboratory Animals
  • Law
  • Mammary Glands
  • Materials
  • Regulations
  • Three Dimensional

Readers

  • Logistics and Supply Chain Management.
  • Molecular Biology and Genetics