The Associate Program in Ethnobiology, Socio-Economic Value Assessment and Community Based Conservation.
Abstract
BDCP conducted extraction and bioassay guided fractionation of active extract leading to the isolation of bioactive compounds. The following plants are in our priority list as potential antimalarial candidate. They include: Picralima nitida, Araliopsis tabouensis, Morinda lucida, Enantia chlorantha, Spathodea campanulata, Synclisia scarbrida, Uvaria chamae, Cryptolepis sanguino1enta, Glossocalyx brevipes, Cleistopholis pawns, Leidobotrys staudtii and Pachypodanthium staudtii. Three compounds derived from a modification of the parent cryptolepine molecule, which showed very significant antimalarial, have been synthesized to enable in vivo testing. Six compounds identified from earlier studies are being evaluated against four strains of Trypanosoma b. brucei and three T.b. rhodesiense clinical isolates. Four new plants namely Plantex vellous, Glossocalyx brevipes, Fagara lemairei, Dorsternia bateri had showed very promising result. Three cryptolepine analogs found to possessing broad-spectrum antiprotozoal activity will be screened in vivo against Cryptosporidium and Toxoplasmosis. Results from the non-specific brine-shrimp studies have been compared with those obtained from our anti-malarial screens. There seems to be a correlation between brine-shrimp toxicity and antimalarial activity. Additional data are being collected to validate this relationship. Significant efforts in database integration into CISAMAP, phytomedicine, socio-economic, valuation studies, training and trust find development were made this year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA373608
Entities
People
- Maurice M. Iwu