Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions.
Abstract
Sulfur mustard (SM) is a powerful chemical warfare vesicant. No efficient pharmacological antidote is available against this blisterogen. The present study demonstrates the protective effect of newly developed iodine preparation for topical treatment after exposure to SM. In the haired guinea pig model, post-exposure treatment with iodine reduced the degree of skin lesions caused by 1 micron1 SM. We have seen that intervals of 15, 30, and 45 min between exposure and treatment caused statistically significant reduction of 93%, 91% and 50%, respectively, in ulceration area. Longer interval of 60 min also reduced the lesion by 50% but without statistical significance. The longer was iodine left on the skin the better was the protection achieved, whereas the best protection was observed when iodine was left 2 hours on skin. There was also relationship between degree of protection and SM dose. GO-MS studies showed that iodine did not chemically modified SM. We continued to attempt identifying the previously reported protective factor produced in iodine-treated skin by HPLC and HPLC-MS. In the near future intensive effort will be invested in this issue and in further establishment of the protective effect of iodine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA373610
Entities
People
- Uri Wormser
Organizations
- Hebrew University of Jerusalem