Preclinical Pharmacodynamic and Pharinacokinetic Studies of Investigational New Drugs
Abstract
During the past contract year, studies were initiated to determine the pharmacokinetics and metabolism of 14Cartelinic acid in male and female dogs, and to investigate the dose-related pharmacodynamic effects of artelinic acid, as assessed by signs of clinical and pathological toxicity, in male and female rats. Results of the pharmacokinetic study indicate that in dogs: the absorption of radioactivity derived from C14artelinic acid is relatively rapid after oral administration of the compound; after either IV or PO administration of C14artelinic acid, radioactivity is detectable in whole blood and plasma for greater than 192 hours after dosing; C14artelinic acid and/or its radiolabeled metabolites appear to undergo biliary excretion; artelinic acid is extensively metabolized. The identity of the metabolites of artelinic acid is currently under investigation. The initial phase of the pharmacodynamic study of artelinic acid in rats is currently in progress and, thus, definitive information is not yet available from this study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA373723
Entities
People
- Patricia E. Noker
Organizations
- Southern Research