A Comparison of Cerebral Blood Flow in Migraineurs During Headache, Headache-Free and Treatment Periods

Abstract

The pathophysiology of migraine remains poorly understood. Sumatriptan has been reported to increase flow velocities in large cerebral arteries, consistent with a vasoconstrictive effect. We report data from a study of tissue cerebral blood flow (CBF) in migraine following treatment with sumatriptan. Methods: Otherwise healthy patients with a minimum of one migraine headache per month (IHS criteria) were scanned using H215O, and positron emission tomography, within 24 hours of the onset of migraine headache. Patients were reimaged 0.25, 0.5 and 1 hours following 6 mg SQ sumatriptan, and after a headache free interval of at least 48 hours.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1999
Accession Number
ADA374068

Entities

People

  • Edward M. Bednarczyk

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anesthesia
  • Arteries
  • Biomedical Research
  • Blood
  • Blood Flow
  • Blood Vessels
  • Cardiovascular Diseases
  • Data Analysis
  • Diseases And Disorders
  • Health Services
  • Materials
  • Measurement
  • Pain
  • Statistical Analysis

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.