Bone-97 Alcohol and Skeletal Adaptation to Mechanical Usage.
Abstract
These studies are designed to determine whether ethanol antagonizes the ability of the skeleton to adapt to increased mechanical usage. Ethanol reversibly alters the biophysical properties of cell membranes. The overall hypothesis to be tested in adult rats is that these membrane changes disrupt essential cell signaling pathways for one or more cytokines, growth factors and polypeptide hormones that regulate bone modeling and remodeling. This report summarizes our progress from the award date (November 1998) through August 31, 1999. During Year 1 of the award we have made progress in completing Tasks 1-5, and Task 8. These tasks include: determination of the dose response and time course effects of administered ethanol (Tasks 1 and 2) on blood alcohol levels, serum chemistry and bone metabolism; determination of which induces a more detrimental skeletal response: peak blood concentration of ethanol or chronic elevation of blood alcohol (Task 3); evaluation of the long-term skeletal effects of ethanol on bone metabolism and strength (Task 4); determination of the effects of ethanol on the skeletal adaptation resistance exercise training (Task 5); determination of the effects of prior consumption of ethanol or PTH-induced increases in mRNA levels for bone matrix proteins (Task 8).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA374142
Entities
People
- Russel Turner
Organizations
- Mayo Clinic