Novel and Selective Inactivators for Matrix Metalloproteases Involved in Breast Cancer Metastasis

Abstract

Matrix metalloproteases (MMPs) are endopeptidases with a diverse set of physiological and pathological functions. Two of these proteases, MMP-2 and MMP-9, also known as gelatinases A and B, respectively, have been implicated in breast tumor metastasis. This research endeavors to prepare the first mechanism-based inactivators for these enzymes, molecules which are expected to show high selectivity in inactivation of the targeted enzymes. Toward this goal, several such putative inactivators were designed and synthesized in the Mobashery laboratory in the past year. Initial characterization with the enzyme indicated that one of these molecules showed the desired inactivating trait, but it exhibited relatively low affinities for the gelatinases. Work in on-going in the design of derivatives of higher affinity.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA374214

Entities

People

  • Shahriar Mobashery

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Aspartic Acid
  • Biochemistry
  • Breast Cancer
  • Cancer
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Glutamic Acid
  • Materials
  • Molecules
  • Neoplasms
  • Sea Urchins
  • Three Dimensional

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics
  • Naval Engineering and Maritime Security
  • Oncology (Cancer Research).