Strategy Toward the Total Synthesis of Epothilones A and B

Abstract

Epothilones are a class of promising anti breast cancer candidate. They were synthesized by four strategies. Structure - activity relationships were studied with the synthetic compounds. The first in vivo test of synthetic epothilone D is encouraging.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA374231

Entities

People

  • Dongfang Meng

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Antineoplastic Agents
  • Cell Physiological Processes
  • Cells
  • Chemical Products
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Organic Chemistry

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Oncology