Repletion of Zinc and Iron Deficiencies Improve Cognition of Premenopausal Women
Abstract
Primary Hypothesis: Repletion of mild zinc (Zn) & iron (Fe) deficiencies will improve neuropsychological performance of women. Design: This is a 16 week double-blind stratified randomized controlled treatment (Rx) trial with a Rx cross-over at 8 weeks. Subjects are 60 Zn & Fe deficient (D) & 20 normal (N) premenopausal women. Before baseline measurements, other potentially limiting nutrients are repleted. Rx includes micronutrients (M) alone, given to 20 D & 20 N subjects for 16 weeks with a pseudo-cross-over at 8 weeks; 30 mg Zn with M, and 30 mg Fe with M, each given to 40 D subjects for 8 weeks, 20 subjects at a time. Outcomes -- include Zn & Fe status, lean body mass (LBM), Zn kinetics. other indices that might be affected by Zn status, and - %neuropsychological performance. Results: Screening plasma zinc concentration in 73 subjects (since start) was (mean i SD) 712 i 85.1 microgram/L. Hair zinc concentrations in 102 subjects (since start) were 174 +/- 65.4 microgram/gram. Platelet, leukocyte and/or lymphocyte Zn concentrations were generally within the reference range.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA374665
Entities
People
- Harold H. Sandstead
Organizations
- University of Texas at Austin