Mechanism of Aromatic Hydrocarbon Induced Mammary Tumorigenesis

Abstract

Recent evidence suggests that the rise in breast cancer rates reflects increased exposure to and bioaccumulation of environmental pollutants, such as 7,12-dimethylbenz(a)anthracene (DMBA). Female Sprague-Dawley rats treated with DMBA develop mammary (breast) tumors by about 15 weeks. Here we proposed to elucidate the roles of the aromatic hydrocarbon (Ah) and estrogen receptors and the c-myc oncogene. The hypothesis investigated was that administration of DMBA would lead to AhR-mediated induction of P-45O enzymes.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA375109

Entities

People

  • Gail E. Sonenshein

Organizations

  • Boston University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Medical Personnel
  • Organic Chemistry
  • Proteins

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics