Molecular Recognition of Endocytic Codes in Receptor Tyrosine Kinases
Abstract
Primary tumors of the breast are not life threatening. Metastasis of primary tumor cells to essential organs pose the main threat to life for people with breast cancer. Metastasis, the process of cells aggressing from the primary tumor site and infiltrating distal tissues, is dependant on cell movement and shape, which in turn are controlled by the cytoskeleton. While cells undergo constant reorganization, the upstream processes that regulate cell shape and movement are not well characterized. The Rho family of GTPases, which include Rho, Rac and Cdc42, were shown to be a common pathway by which signal transduction cascades regulate cell shape and motility. Recently, LIM kinase was shown to regulate the actin cytoskeleton via phosphorylation and inactivation of the actin depolymerizing protein cofilin and be downstream of Rac.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1999
- Accession Number
- ADA375148
Entities
People
- David Edwards
Organizations
- University of California, San Diego