Repletion of Zinc and Iron Deficiencies Improve Cognition of Premenopausal Women
Abstract
Primary Hypothesis: Repletion of mild zinc (Zn) & iron (Fe) deficiencies will improve neuropsychological performance of women. Design: This is a 16 week double-blind stratified randomized controlled treatment trial with a treatment cross-over at 8 weeks. The subjects are 60 Zn & Fe deficient (D) & 20 normal (N) premenopausal women. Other potentially limiting nutrients are repleted before collection of baseline data. Treatments are: micronutrients (M) alone, given to 20 D & 20 N subjects for 16 weeks with a pseudo-cross-over at 8 weeks; 30 mg Zn with M and 30 mg Fe with M, each given to 40 D subjects for 8 weeks followed by a cross over to the other treatment. Outcomes include indices of Zn & Fe status, lean body mass (LBM), other indices that might be affected by Zn status, and neuropsychological performance. Results: The treatment trial was completed. Completion of laboratory and data analysis is in process.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA375226
Entities
People
- Harold H. Sandstead
Organizations
- University of Texas at Austin