Gene Transfer Studies of the Pathogenesis and Treatment of Parkinson's Disease.

Abstract

The overall aim of this research is to use a recombinant multiply deleted genomic herpes simplex virus type-i (HSV-i) based gene transfer vector to test the hypotheses that gene transfer of the glial derived neurotrophic factor (GDNF) or bcl-2 can slow or prevent the apoptosic death of nigral neurons in animal models of PD, and that expression of tyrosine hydroxylase (TH) can improve symptoms.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1999
Accession Number
ADA375299

Entities

People

  • Joseph C. Glorioso

Organizations

  • University of Pittsburgh

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gene Therapy
  • Genetics
  • Health Services
  • Neurons
  • Neuropathy
  • Parkinson'S Disease
  • Peptide Growth Factors
  • Peripheral Nervous System
  • Proteins
  • Virion

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Virology (or Medical Virology).