99MTC Alpha-Fetoprotein: A Novel, Specific Agent for the Detection of Human Breast Cancer.
Abstract
A non-invasive, and accurate imaging technique is needed to further evaluate mammographically suspicious lesions to reduce the number of cancer negative biopsies. We have demonstrated that technetium-99m radiolabeled human alpha-fetoprotein (99mTc AFP) localizes in human breast cancer cells in-vivo, most likely concentrating in breast cancer cells due to a specific receptor not found in normal adult breast tissue. Our technical objective is to assess 99mTc AFP as an agent to detect and stage human breast cancer. Following the first two aims of the award work scope, we have compared natural full-length and recombinant domain III preparations of 99mTc AFP to tracers now used to detect breast cancer, T1 and 99mTc sestamibi. Our imaging results in immune-deficient (SCID) mice bearing human cancer xenografts confirm our hypothesis that 99mTc AFP is a superior human breast cancer imaging agent. We have also demonstrated that 99m AFP imaged pulmonary metastases in a rat model of breast cancer. During the extension effort we will continue the work scope for these aims and further determine the ability of 99mTc AFP to image metastases from a transplantable rat mammary cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1999
- Accession Number
- ADA376180
Entities
People
- Bruce Line
Organizations
- Albany Medical College