Synaptic Plasticity and Memory Formation

Abstract

Work from this laboratory demonstrated that receptors with integrin epitopes, and that bind to the consensus RGD (arginine-glycine-aspartate) sequence, are concentrated in forebrain synapes. Light and electron microscopic immunocytochemical experiments from other groups then showed that subunits are present in hippocampus and that subunits are highly concentrated in hippocampal synapses. A critical issue for adhesion hypothesis of LTP consolidation concerns the route whereby extant adhesive relationship are disrupted so as to allow new configurations to emerge. This is less of problem for integrins that for NCAMs because breakdown of the spectrin network by calpain would have profound effect on relationships between the integrins and the sybsynaptic cytoskeleton. AFOSR supported work has now identified a route whereby the triggers for LTP could also relax NCAM mediated adhesion.

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Document Details

Document Type
Technical Report
Publication Date
Mar 21, 2000
Accession Number
ADA376184

Entities

People

  • Gary Lynch

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Adhesives
  • Anatomy
  • Brain
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytoskeleton
  • Electrons
  • Frequency
  • Hippocampus
  • Integrins
  • Modulators
  • Molecules
  • Pilot Studies
  • Plastic Properties

Readers

  • Neuroscience
  • Oncology (Cancer Research).

Technology Areas

  • Microelectronics