Early Detection of NF1 Brain Tumor Growth and Treatment Response by MRI, MRS and PET in a Trial of Novel Antitumor Drugs

Abstract

This, the final report for all clinical research studies conducted under the US Army BAA for Neurofibromatosis type 1, reviews the progress made between January, 1994 (Army approved start date) and October, 1997 (completion of data accrual for all studies) concerning the conduct and preliminary results from NF-1 Clinical Trials Consortium studies. It is organized into three sections: (1) a description of the clinical trials structure and organization; (2) a review of the randomized phase II clinical trial results for the treatment of NF-I patient with optic pathway I hypothalamic gliomas or plexiform neurofibromas; (3) a review of the methods development and results for multimodality neuroimaging studies in NF-i patients with newly-diagnosed or progressive optic pathway / hypothalamic gliomas or brain stem gliomas.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA376214

Entities

People

  • Peter C. Phillips

Organizations

  • Children's Hospital of Philadelphia

Tags

DTIC Thesaurus Topics

  • Brain
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Neuromuscular Diseases
  • Peripheral Nervous System

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Oncology
  • Technical Research and Report Writing.