NKX3.1 In Prostate Cancer.

Abstract

We have isolated a prostate-specific gene, NKX3.1, that maps to chromosome 8p21, a common region for loss of heterozygosity in human prostate cancer. NKX3.1 is a homeobox gene that is expressed at high levels in adult human prostate. Deletion of NKX3.1 in the mouse has suggested that NKX3.1 has a suppressor effect on pro static epithelial cell growth, and that haploinsufficiency is sufficient to produce epithelial hyperplasia. Inconsistent with the interpretation that NKX3.1 is a classical tumor suppressor gene, the coding region of NKX3.1 is not mutated in human prostate cancer. This is the first annual report of a project that seeks to determine the significance of NKX3.1 in prostate cancer. We have shown that a genetic polymorphism that changes DNA-binding properties of the NKX3.1 protein is present in approximately 10% of the human population and is not strongly associated with prostate cancer risk. We continue to investigate whether the R52C NKX3.l polymorphism influences the development of prostatic hyperplasia. We have derived a specific antibody to human NKX3.1 and are investigating control of expression of NKX3.1 in human prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA376365

Entities

People

  • Edward P. Gelmann

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Blood
  • Cancer
  • Cells
  • Chemistry
  • Epithelial Cells
  • Genetic Structures
  • Genetic Variation
  • Genetics
  • Hyperplasia
  • Immune Serums
  • Medical Personnel
  • Neoplasms
  • Polymerase Chain Reaction
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • European Security and Defence Policy (ESDP).
  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology