Malaria Genome Sequencing Project.
Abstract
The objectives of this 5-year Cooperative Agreement between TIGR and the Malaria Program, NMRC, were to: Specific Aim 1, sequence 3.5 Mb of P. falciparum genomic DNA; Specific Aim 2, annotate the sequence; Specific Aim 3, release the information to the scientific community. To date, we have published the first complete sequence of a malarial chromosome (chromosome 2 4 ), completed the random phase sequencing of 3 other large chromosomes totaling 7.2 Mb, and have initiated functional genomics studies using glass slide micorarrays to characterize the expression of chromosome 2, 3, and 14 genes throughout the erythrocytic cycle. We have also collaborated in the construction of a two-enzyme optical restriction map of the entire P. falciparum genome 7 , and are continuing to further develop the GlimmerM gene finding software developed in year 1. In addition, we have begun small scale sequencing of the rodent malaria P. yoelii and are collaborating in the sequencing of part of a P. vi vax chromosome. Discussions with the Malaria Program, NMRC aimed at development of a program to use genomics and functional genomics to accelerate vaccine research are in progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2000
- Accession Number
- ADA376886
Entities
People
- Malcolm J. Gardner
Organizations
- J. Craig Venter Institute