TGFa-myc Interactions in Mammary Tumorigenesis.
Abstract
This grant studied the nature of the synergistic interaction of the growth factor TCFa and the nuclear protoonco-protein'product c-Myc for bitransgenic mouse mammary tumorigenesis. We found evidence of a multifactoral interaction of the two genes, involving cooperative stimulation of proliferation, anchorage independent colony formation, suppression of cell death (apoptosis), and chromosomal destabilization. In addition, we observed that the TGFalpha-related growth factors amphiregulin and cripto-l were likely to have tumor promoting effects similar to TGFalpha in breast cancer. Further studies addressed the ability of c-Myc and TGFalpha to interact in a novel paracrine mammary system in vivo. In summary, this grant allowed the development of a new model system whereby the interactions of two important genes in breast cancer may be dissected in vivo at the molecular level.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA377913
Entities
People
- Robert B. Dickson
Organizations
- Georgetown University