Preventive Role of Specific Dietary Factors and Natural Compounds Against DNA Damage and Oxidative Stress.

Abstract

I have developed a series of reagents and a luciferase-based functional assay for identifying and testing ligands for Notch4 receptor. I am in the process of testing several candidate genes for their ability to activate Notch4 receptor. In addition, I identified a novel negative regulator of Notch activity, SEL-10. Through biochemical studies, I have shown that SEL-10 interacts with Notch in a domain specific and probably phosphorylation-dependent manner. I also provided some evidence indicating that SEL-10 can regulate Notch ubiquitination in the cell. These results support my model that SEL-10 inhibits Notch activity by targeting it for ubiquitin-mediated protein degradation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADA377925

Entities

People

  • Guangyu Wu

Organizations

  • Columbia University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Cell Line
  • Cells
  • Chemistry
  • Degradation
  • Endothelial Cells
  • Epithelial Cells
  • Genetic Structures
  • Immune Serums
  • Mammary Glands
  • Materials
  • Molecules
  • Neoplasms
  • Oxidative Stress
  • Phosphorylation
  • Proteins
  • Steady State

Fields of Study

  • Biology

Readers

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