Herpes Virus Therapy of Prostate Cancer.
Abstract
Our goal was to develop herpes vectors to treat prostate cancer in order to acquire the necessary data to advance toward clinical trials. We have studied G207, a multiple-mutated conditionally- replicating herpes simplex virus with deletions of both copies of gamma, 34.5 genes and a lacZ insertion disabling the ICP6 gene. We demonstrated that G207 is: 1, highly cytolytic in vitro to four of four human prostate cell lines tested in vitro; 2, effective in treating and capable of curing two different human prostate cancers grown in athymic mice; 3, effective in vivo on both hormone sensitive and on hormone refractory prostate cancers; 4, effective in vivo in human prostate cancer that is recurrent after radiation therapy. Current studies include the use of a syngeneic system for study of these effects and studies of potential toxicity of this form of therapy in order to progress to human trial.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA377977
Entities
People
- Robert L. Martuza
Organizations
- Georgetown University