Angiogenesis Regulates Prostate Cancer Metastasis.
Abstract
The progression of primary and metastatic prostate cancer depends upon the establishment of an adequate blood supply. The purpose of our ongoing research is to evaluate the relevance of angiogenesis in the pathogenesis of prostate cancer. We are evaluating the relationship of the expression of the angiogenesis factors bFGF, VEGF, and IL-8 with prostate cancer growth and metastasis, using our orthotopic model of metastatic prostate cancer in nude mice. Using sense and antisense technology we have enforced the expression of IL-8 by prostate cancer cells prior to their implantation into the prostate of nude mice and evaluated the causality between the expression of this angiogenic factor by human prostate cancer growing in nude mice, tumorigenesis, tumor induced angiogenesis, and metastasis. Similar studies with bFGF and VEGF are in progress. Once the relationship between angiogenesis factor expression and tumor virulence is established, we will target the expression of these factors by human prostate cancer established in nude mice with antisense gene therapy. To complement these studies we are evaluating the expression of VEGF, IL-8, and bFGF by human prostate cancer to determine their relationship to progression in patients. Increasing VEGF mRNA levels are highly associated with advancing pathologic stage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA378066
Entities
People
- Curtis A. Pettaway
Organizations
- The University of Texas MD Anderson Cancer Center