The Relatonship Between Endocrine Factors and Breast Cancer Risk
Abstract
The present study is designed to examine the relationships between hyperinsulinemia, insulin like growth factor-1, central adiposity, maximal adult weight, physical fitness and breast cancer risk in post-menopausal African-American women. The research design is a case-control study of women 55 to 79 years of age. Eligibility criteria for the cases will be newly histologically confirmed primary breast cancer. Both cases and controls will be identified during the same time frame and will come from the same population base. None of the controls will have a previous history of malignant or gynecological conditions that may have the same risk factors in breast cancer. Plasma levels of IGF-1 and insulin will be measured by radioimmunoassay. Central adiposity will be measured as waist-to-hip ratios (WHR). Multiple logistic regression will be used to determine age adjusted odds ratios for tertiles of waist, hip, WHR, maximal adult weight gain and levels of physical activity. Corresponding 95 percent confidence intervals will be based on the logistic regression models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA378095
Entities
People
- Tanya D. Agurs-collins
Organizations
- Howard University