Biochemistry and Molecular Mechanisms of Wingless Action.
Abstract
Our goal is to understand how intercellular signaling pathways are used to regulate growth and differentiation in multicellular organisms. We have focused on the wingless/Wntl pathway, and in particular, on the extracellular events that mediate wingless signaling. During this grant period we have made significant progress in four areas: (1) We have shown that the Wingless protein (Wg) undergoes multiple post- translational modifications; (2) Wg can signal through multiple Frizzled receptors; (3) Glycosaminoglycans stimulate Wg signaling and can function as determinants for defining receptor specificity; (4) Wg binding to Frizzled-Related-Proteins is not sufficient to trigger signaling. Rather signal transmission is a multi-step process.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA378894
Entities
People
- Susan Cumberledge
Organizations
- University of Massachusetts Amherst