IGF-IR Signaling in Breast Cancer.
Abstract
Clinical and experimental evidence suggest that the insulin-like growth factor receptor type 1 (IGF-IR) is involved in breast cancer etiology. IGF-IR is overexpressed in breast tumors (relative to normal breast epithelium) and high levels of IGF-I (IGF-IR ligand) correlate with breast cancer risk in premenopausal women. In vitro, IGF-IR regulates breast cancer proliferation and survival. In addition, we and others have shown that IGF-IR signaling plays a role in the development of estrogen- independence and antiestrogen-resistance. It is now becoming evident that the activation of mitogenic and anti-apoptotic functions of IGF-IR may be critical in primary tumor growth and the early stage of tumorigenesis, however, the involvement of IGF-IR in growth-unrelated processes which may regulate cell spread and cancer metastasis (cell adhesion, motility, chemoattraction) is not clear. To address this problem, we developed several cell lines expressing IGF-IR mutants. The clones will be used to map signaling pathways involved in intercellular adhesion, migration and chemoattraction. The future work will extend our findings reported here that breast cancer cell adhesion and migration on fibronectin involves a dynamic interaction between an IGF-IR substrate SHC and alphaSbetal integrin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA378975
Entities
People
- Ewa Surmacz
Organizations
- Thomas Jefferson University