Biology of Somatostatin and Somatostatin Receptors in Breast Cancer

Abstract

Analysis of SSTR1-5 mRNA expression by semiquantitative RT-PCR in two separate batches of primary ductal NOS breast cancer (n, N 48 and 50) has revealed a strong positive correlation (p , 0.001) between SSTR3 expression and tumor grade suggesting that SSTR3 induction in high grade tumors may represent a compensatory mechanism for regulating proliferative activity through apoptosis. Expression of SSTR1, 2, and 4 strongly correlates with estrogen receptor levels and SSTR2 expression additionally correlates positively with progesterone receptor levels. Tamoxifen exhibits a dose-dependent biphasic effect on SSTR1 and SSTR5 mRNA, low doses being inhibitory and high doses being stimulatory.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA379302

Entities

People

  • Yogesh C. Patel

Organizations

  • McGill University

Tags

DTIC Thesaurus Topics

  • Brain
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics
  • Toxicology/Environmental Toxicology