Cellular Interactions in the Suprachiasmatic Nucleus.
Abstract
We studied neurochemical mechanisms related to control of the activity of these cells. Modulation of the neuronal activity here plays animportant role in determining the phase of the circadian cycle. We examined neuromodulation of GABA and glutamate actions in cells of the SCN. Neuromodulation is based on the concept that neuromodulators can alter the release or response of SCN cells to the fast-acting neurotransmitters GABA and glutamate that regulated inhibition and excitation in the SCN, respectively. In general, this is important because we can understand how the activity of these neurons is modulated by neurotransmitters, we may be able to understand how to alter the temporal regulation of circadian cycles, important for improving human performance during what is commonly known as "jet lag".
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 10, 2000
- Accession Number
- ADA379480
Entities
People
- Anthony Van Den Pol
Organizations
- Yale University