Using Mode of Action of Assess Health Risks From Mixtures of Chemical/Physical Agents

Abstract

Mixtures of carcinogenic chemicals are a major problem in ground water and soils on DoD and DOE facilities. While there is frequently data available for interactions between chemicals to judge risks from short term exposures, data that describe how interactions influence the development of cancer are very rare. This is largely because of the high cost associated with conducting complex interaction studies over the lifetime of experimental animals. Therefore, it is important that the limited resources that are available for studying interactions be directed towards the development of general principles that can be applied to wide variety of circumstances. The co-occurrence of chlorinated solvents at DoD and DOE facilities such as trichloroethylene (TCE), tetrachloroethylene (PERC) and carbon tetrachloride (CT) is a case in point.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1998
Accession Number
ADA379649

Entities

Organizations

  • Air Force Research Laboratory

Tags

DTIC Thesaurus Topics

  • Air Force Facilities
  • Alkenes
  • Animals
  • Carbon Tetrachloride
  • Cells
  • Chemistry
  • Chlorinated Hydrocarbons
  • Drinking Water
  • Experimental Design
  • Groundwater
  • Hazardous Waste
  • Health
  • Hydrocarbons
  • Laboratory Animals
  • Metabolism
  • Metabolites
  • Neoplasms

Fields of Study

  • Environmental science

Readers

  • Analytical Chemistry
  • Groundwater Contamination Remediation.
  • Systems Analysis and Design