Effect of Hypercholesterolernia on Cutaneous Vascular Responses to Exercise in Healthy, Exercise-Trained, Heat-Acclimated Humans
Abstract
The purpose of this research was to determine whether healthy, exercise-trained, heat-acclimated people with one major risk factor for coronary artery disease (high total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C)) would have different cutaneous vascular responses to exercise in a warm environment compared to people who were of similar age and gender who did not share the risk factor. It was hypothesized that individuals who had an elevated TC/HDL-C would have similar deleterious effects on the cutaneous vasculature as the coronary arteries and aorta as observed in pathological studies. That is, individuals who have a high TC/HDL-C ratio might have less compliant cutaneous vessels and therefore impaired sensible heat loss than individuals who have a low TC/HDL-C ratio. In the current study, we measured cutaneous vascular responses using noninvasive instruments during rest and exercise in a warm environment in individuals with either a high or low TC/HDL-C ratio. Obtaining evidence for impaired heat dissipation was limited by the conservative study design because the volunteers were studied in a moderately hot environment with a moderate humidity rather than a hot environment because half of the study population, by definition, was at risk for coronary artery disease. Subjects in both groups routinely exercised and were heat-acclimated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA379853
Entities
People
- Brent S. Mair
- Catherine G. Boulant
- Janet Staab
- Lou A. Stephenson
- Scott B. Robinson
Organizations
- United States Army Research Institute of Environmental Medicine